Malaria Vaccine Development

Presentacion 1 cs protein y ratones

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M

Malaria

Malaria is a devastating tropical disease affecting 100 countries worldwide. Plasmodiumfalciparum and P. vivax are the predominant parasite species responsible for 300--500 million clinical cases per year.

P. vivax

• Most prevalent in Asian and American continent
•  High mobility and low mortality
•  P. vivax genome is estimate on 30 Mb, 14 chromosomes and proximately 5000 to 6000 genes

Difficulties to in vitro isolation

Different stage vaccine target

The proposed mechanisms for vaccine elicited immunity at

the different stages include: (1) at the pre-erythrocytic stage,

antibody-mediated blockage of hepatocyte invasion by sporozoites32

and inhibition of development of liver stage schizonts; (2)

at the asexual erythrocytic stage, antibody-mediated blockage of

erythrocyte invasion by merozoites and arrest of development

of blood stage schizonts by soluble immune mediators or antibodies;

33 and (3) during parasite sexual development, antibodymediated

blockage fertilization and further development in the

mosquito midgut.34,35 Of the different parasite life cycle stages,

only the asexual erythrocytic stage causes clinical symptoms

The pre-erythrocytic phase of development occurs without clinical

manifestation and the sexual reproduction takes place into

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994342/pdf/JCI44423.pdfhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994342/pdf/JCI44423.pdf